120993-53-5
120993-53-5 structure
- Name: Desirudin
- Chemical Name: Desirudin
- CAS Number: 120993-53-5
- Molecular Formula: C287H440N80O110S6
- Molecular Weight:
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
- Create Date: 2018-10-16 18:57:00
- Modify Date: 2025-08-25 07:30:47
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Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction[1][2].
| Name | Desirudin |
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| Description | Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction[1][2]. |
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| Related Catalog | |
| Target |
ED50: 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2]. |
| In Vivo | Desirudin (CGP 39393, 0.75-3.0 mg/kg, a bolus plus infusion administration, dogs model of cardiopulmonary bypass) is effective in Inhibiting clot formation[1]. Desirudin (0.01-1 mg/kg approximately, Intravenous injections and subcutaneous injection, rat shunt model) inhibits thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.), and inhibits venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2]. Animal Model: Male mongrel dogs model of cardiopulmonary bypass[1] Dosage: 1.0 mg/kg + 0.75 mg/kg/h, 1.0 mg/kg + 1.50 mg/kg/h, 1.0 mg/kg + 2.25 mg/kg/h, 1.0 mg/kg + 3.0 mg/kg/h. Administration: Administered as a bolus plus infusion Result: Inhibits clot formation with no adverse hemodynamic or hematologic effects. Animal Model: Rat shunt model of thrombus formation on a cotton-thread[2] Dosage: 0.01-1 mg/kg approximately Administration: Intravenous injections, subcutaneous injection Result: Inhibited thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.). Inhibited venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.). |
| References |
| Molecular Formula | C287H440N80O110S6 |
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