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1314378-12-5

1314378-12-5 structure
1314378-12-5 structure
  • Name: Bis-PEG4-PFP ester
  • Chemical Name: Bis-PEG4-PFP ester
  • CAS Number: 1314378-12-5
  • Molecular Formula: C24H20F10O8
  • Molecular Weight: 626.395
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-10-17 20:07:50
  • Modify Date: 2024-01-10 13:34:11
  • Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Bis-PEG4-PFP ester
Synonyms Bis(pentafluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate
MFCD21363293
4,7,10,13-Tetraoxahexadecane-1,16-dioic acid, bis(2,3,4,5,6-pentafluorophenyl) ester
Description Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.5±0.1 g/cm3
Boiling Point 570.5±50.0 °C at 760 mmHg
Molecular Formula C24H20F10O8
Molecular Weight 626.395
Flash Point 287.7±25.0 °C
Exact Mass 626.099854
LogP 3.92
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.463