1314378-12-5

1314378-12-5 structure

Name: Bis-PEG4-PFP ester
Chemical Name: Bis-PEG4-PFP ester
CAS Number: 1314378-12-5
Molecular Formula: C₂₄H₂₀F₁₀O₈
Molecular Weight: 626.395
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-10-17 20:07:50
Modify Date: 2024-01-10 13:34:11
Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Bis-PEG4-PFP ester
Synonyms	Bis(pentafluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate MFCD21363293 4,7,10,13-Tetraoxahexadecane-1,16-dioic acid, bis(2,3,4,5,6-pentafluorophenyl) ester

Description	Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.