Name | H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH |
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Synonyms | TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL (DISULFIDE BRIDGE: CYS23-CYS29) |
Description | Osteocalcin (1-49) (human) is a vitamin K-dependent bone specific protein. Osteocalcin (1-49) (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces[1][2]. |
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Related Catalog | |
In Vitro | Up to 20% of all non-collagenous protein in human bone consists of Osteocalcin. Only minor amounts of Osteocalcin are secreted into the blood circulation where it can be measured by immunochemical methods[1]. Osteocalcin in serum is supposedly derived from newly synthesized bone, and the amount of this protein in serum may be a very specific marker for bone formation rate[1]. Osteocalcin (1 nM-1 μM) is chemotactic for breast cancer cells and osteoblast-like osteogenic sarcoma cells as well as monocytes, and causes their unidirectional migration[2]. Osteocalcin peptide contains 49 amino acids, with subsequent breakdown to fragments 1–19, 20–49, 20–43, 1–43, and 44–49 in the liver, kidney, and serum[3]. |
Molecular Formula | C269H381N67O82S2 |
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Molecular Weight | 5929.43 |
Appearance | solid |
Storage condition | −20°C |
RIDADR | NONH for all modes of transport |
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WGK Germany | 3 |