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1415800-35-9

1415800-35-9 structure
1415800-35-9 structure
  • Name: Mal-Amido-PEG4-Boc
  • Chemical Name: Mal-Amido-PEG4-t-butyl ester
  • CAS Number: 1415800-35-9
  • Molecular Formula: C22H36N2O9
  • Molecular Weight: 472.529
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-29 11:36:22
  • Modify Date: 2024-01-23 19:15:14
  • Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Mal-Amido-PEG4-t-butyl ester
Synonyms MAL-NH-PEG4-CH2CH2COOTBU
Description Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.2±0.1 g/cm3
Boiling Point 626.4±55.0 °C at 760 mmHg
Molecular Formula C22H36N2O9
Molecular Weight 472.529
Flash Point 332.6±31.5 °C
Exact Mass 472.242096
LogP -0.57
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.496