Mal-Amido-PEG4-Boc

Modify Date: 2024-01-23 19:15:14

Mal-Amido-PEG4-Boc Structure
Mal-Amido-PEG4-Boc structure
Common Name Mal-Amido-PEG4-Boc
CAS Number 1415800-35-9 Molecular Weight 472.529
Density 1.2±0.1 g/cm3 Boiling Point 626.4±55.0 °C at 760 mmHg
Molecular Formula C22H36N2O9 Melting Point N/A
MSDS N/A Flash Point 332.6±31.5 °C

 Use of Mal-Amido-PEG4-Boc


Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-Amido-PEG4-t-butyl ester
Synonym More Synonyms

 Mal-Amido-PEG4-Boc Biological Activity

Description Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 626.4±55.0 °C at 760 mmHg
Molecular Formula C22H36N2O9
Molecular Weight 472.529
Flash Point 332.6±31.5 °C
Exact Mass 472.242096
LogP -0.57
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.496

 Synonyms

MAL-NH-PEG4-CH2CH2COOTBU
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