1426164-53-5

1426164-53-5 structure

Name: Bis-Mal-Lysine-PEG4-TFP ester
Chemical Name: Bis-Mal-Lysine-PEG4-TFP ester
CAS Number: 1426164-53-5
Molecular Formula: C₃₇H₄₅F₄N₅O₁₃
Molecular Weight: 843.773
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-16 11:01:50
Modify Date: 2024-01-14 12:23:32
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Bis-Mal-Lysine-PEG4-TFP ester
Synonyms	Bis-MAL-Lysine-dPEG(R)4-TFP ester 2,3,5,6-Tetrafluorophenyl 1-({N2,N6-bis[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]lysyl}amino)-3,6,9,12-tetraoxapentadecan-15-oate MFCD28385461 4,7,10,13-Tetraoxa-16,23-diazahexacosan-1-oic acid, 26-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-18-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-17,24-dioxo-, 2,3,5,6-tetrafluorophenyl ester

Description	Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562