- DC Chemicals Limited
- China
- Product Name: Super-TDU
- Price: $950.0/100mg $1900.0/250mg $3800.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Super-TDU
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
1599441-71-0
1599441-71-0 structure
- Name: Super-TDU
- Chemical Name: Super-TDU
- CAS Number: 1599441-71-0
- Molecular Formula: C237H370N66O69S
- Molecular Weight: 5279.94
- Catalog: Signaling Pathways Stem Cell/Wnt YAP
- Create Date: 2018-07-21 21:07:51
- Modify Date: 2024-01-14 10:07:21
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Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model[1].
| Name | Super-TDU |
|---|
| Description | Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Super-TDU downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27[1]. |
| In Vivo | Super-TDU (intravenous injection; 50 μg/kg or 500 μg/kg; per day) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner in mice[1]. Super-TDU (intravenous injection; 250 μg/kg 500 μg/kg) has the t1/2α of 0.78 hours and 0.82 hours; the Cmax of 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively[1]. Animal Model: BALB/cA nu/nu mice[1] Dosage: 50 μg/kg or 500 μg/kg Administration: Intravenous Injection; per day Result: Decreased the sizes, weights of tumors, and YAP target genes in a dose-dependent manner. Animal Model: BALB/cA nu/nu mice[1] Dosage: 250 μg/kg or 500 μg/kg (Pharmacokinetic Study) Administration: Intravenous Injection Result: The t1/2α is 0.78 hours and 0.82 hours; the Cmax is 6.12 ng/mL and 13.3 ng/mL; the CL is7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively. |
| References |
| Molecular Formula | C237H370N66O69S |
|---|---|
| Molecular Weight | 5279.94 |
| Storage condition | -20℃ |