1613710-01-2

1613710-01-2 structure

Name: ARN-3236
Chemical Name: ARN-3236
CAS Number: 1613710-01-2
Molecular Formula: C₁₉H₁₆N₂O₂S
Molecular Weight: 336.41
Catalog: Signaling Pathways Immunology/Inflammation Salt-inducible Kinase (SIK)
Create Date: 2018-07-13 11:57:15
Modify Date: 2024-01-11 15:52:23
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2) (IC50 <1 nM), with activity in inhibiting growth and enhancing paclitaxel sensitivity in cultures and xenografts of ovarian cancer cell lines[1][2].

Name	ARN-3236
Synonyms	3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE

Description	ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2) (IC50 <1 nM), with activity in inhibiting growth and enhancing paclitaxel sensitivity in cultures and xenografts of ovarian cancer cell lines[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)
Target	SIK2:<1 nM (IC50) SIK1:21.63 nM (IC50) SIK3:6.63 nM (IC50)
References	[1]. Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99(5):711-21. [2]. Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954.