1644069-80-6
1644069-80-6 structure
- Name: DDR Inhibitor
- Chemical Name: N-(5-((3-(3-fluorophenyl)ureido)methyl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide
- CAS Number: 1644069-80-6
- Molecular Formula: C23H20FN5O2
- Molecular Weight: 417.4356032
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Discoidin Domain Receptor
- Create Date: 2018-06-20 10:41:44
- Modify Date: 2025-08-25 11:15:49
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DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.
| Name | N-(5-((3-(3-fluorophenyl)ureido)methyl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide |
|---|---|
| Synonyms | DDR Inhibitor |
| Description | DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM. |
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| Related Catalog | |
| Target |
IC50: 3.3 nM (DDR2)[1] IC53: 1.5 nM (DDR1)[1] |
| In Vitro | DDR Inhibitor (Example 6) is a potent DDR inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM[1]. |
| Kinase Assay | Europium Kinase binding assay is used. Compounds (DDR Inhibitor, etc.) are incubated with 0.5 nM DDR1 or 0.25 nM DDR2 for 1 hour at room temperature in low volume black 384 well assay plates containing 5 nM or 10 nM Kinase Tracer 178 respectively and 2 nM Europium labelled anti-GST antibody in assay buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 1 mM EGTA and 0.01 % BRIJ35). The ratio of fluorescence emission 665 nm/615 nm after excitation at 340 nm is obtained. IC50 values are determined from dose-response plots using nonlinear least-squares analysis[1]. |
| References |
[1]. Gordon Saxty, et al. Imidazo-condensed bicycles as inhibitors of discoidin domain receptors (ddrs) |
| Molecular Formula | C23H20FN5O2 |
|---|---|
| Molecular Weight | 417.4356032 |
| Storage condition | 2-8℃ |