DDR Inhibitor

Modify Date: 2024-01-02 18:52:36

DDR Inhibitor Structure
DDR Inhibitor structure
Common Name DDR Inhibitor
CAS Number 1644069-80-6 Molecular Weight 417.4356032
Density N/A Boiling Point N/A
Molecular Formula C23H20FN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DDR Inhibitor


DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.

 Names

Name N-(5-((3-(3-fluorophenyl)ureido)methyl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide
Synonym More Synonyms

 DDR Inhibitor Biological Activity

Description DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.
Related Catalog
Target

IC50: 3.3 nM (DDR2)[1] IC53: 1.5 nM (DDR1)[1]

In Vitro DDR Inhibitor (Example 6) is a potent DDR inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM[1].
Kinase Assay Europium Kinase binding assay is used. Compounds (DDR Inhibitor, etc.) are incubated with 0.5 nM DDR1 or 0.25 nM DDR2 for 1 hour at room temperature in low volume black 384 well assay plates containing 5 nM or 10 nM Kinase Tracer 178 respectively and 2 nM Europium labelled anti-GST antibody in assay buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 1 mM EGTA and 0.01 % BRIJ35). The ratio of fluorescence emission 665 nm/615 nm after excitation at 340 nm is obtained. IC50 values are determined from dose-response plots using nonlinear least-squares analysis[1].
References

[1]. Gordon Saxty, et al. Imidazo-condensed bicycles as inhibitors of discoidin domain receptors (ddrs)

 Chemical & Physical Properties

Molecular Formula C23H20FN5O2
Molecular Weight 417.4356032
Storage condition 2-8℃

 Synonyms

DDR Inhibitor
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