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1682653-80-0

1682653-80-0 structure
1682653-80-0 structure
  • Name: Tetrazine-Ph-PEG5-NHS ester
  • Chemical Name: Tetrazine-PEG5-NHS ester
  • CAS Number: 1682653-80-0
  • Molecular Formula: C27H36N6O10
  • Molecular Weight: 604.609
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-10 12:31:18
  • Modify Date: 2024-01-10 11:43:58
  • Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Tetrazine-PEG5-NHS ester
Synonyms 19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-N-[4-(1,2,4,5-tetrazin-3-yl)benzyl]-4,7,10,13,16-pentaoxanonadecan-1-amide
Tz-PEG5-NHS
4,7,10,13,16-Pentaoxanonadecan-1-amide, 19-[(2,5-dioxo-1-pyrrolidinyl)oxy]-19-oxo-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]-
MFCD28505547
Tetrazine-PEG5-NHS ester
Description Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.4±0.1 g/cm3
Molecular Formula C27H36N6O10
Molecular Weight 604.609
Exact Mass 604.249268
LogP -4.14
Index of Refraction 1.570