Tetrazine-Ph-PEG5-NHS ester

Modify Date: 2024-01-10 11:43:58

Tetrazine-Ph-PEG5-NHS ester Structure
Tetrazine-Ph-PEG5-NHS ester structure
Common Name Tetrazine-Ph-PEG5-NHS ester
CAS Number 1682653-80-0 Molecular Weight 604.609
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C27H36N6O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tetrazine-Ph-PEG5-NHS ester


Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Tetrazine-PEG5-NHS ester
Synonym More Synonyms

 Tetrazine-Ph-PEG5-NHS ester Biological Activity

Description Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C27H36N6O10
Molecular Weight 604.609
Exact Mass 604.249268
LogP -4.14
Index of Refraction 1.570

 Synonyms

19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-N-[4-(1,2,4,5-tetrazin-3-yl)benzyl]-4,7,10,13,16-pentaoxanonadecan-1-amide
Tz-PEG5-NHS
4,7,10,13,16-Pentaoxanonadecan-1-amide, 19-[(2,5-dioxo-1-pyrrolidinyl)oxy]-19-oxo-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]-
MFCD28505547
Tetrazine-PEG5-NHS ester
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