1694731-93-5

1694731-93-5 structure

Name: Propargyl-PEG3-CH2COOH
Chemical Name: Azido-PEG4-CH2CO2H
CAS Number: 1694731-93-5
Molecular Formula: C₁₁H₁₈O₆
Molecular Weight: 246.26
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-11-30 21:34:48
Modify Date: 2024-01-09 02:10:33
Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	Azido-PEG4-CH2CO2H

Description	Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.