1818294-47-1

1818294-47-1 structure

Name: Azido-PEG6-PFP ester
Chemical Name: Azido-PEG6-PFP ester
CAS Number: 1818294-47-1
Molecular Formula: C₂₁H₂₈F₅N₃O₈
Molecular Weight: 545.454
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-04 23:32:14
Modify Date: 2024-01-17 16:45:25
Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Azido-PEG6-PFP ester
Synonyms	3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-azido-, 2,3,4,5,6-pentafluorophenyl ester Pentafluorophenyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate MFCD26793784

Description	Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562