1818294-48-2

1818294-48-2 structure

Name: Azido-PEG5-PFP ester
Chemical Name: Azido-PEG5-PFP ester
CAS Number: 1818294-48-2
Molecular Formula: C₁₉H₂₄F₅N₃O₇
Molecular Weight: 501.402
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-26 06:47:38
Modify Date: 2025-08-24 21:08:09
Azido-PEG5-PFP ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	Azido-PEG5-PFP ester
Synonyms	MFCD26793782 3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-azido-, 2,3,4,5,6-pentafluorophenyl ester Pentafluorophenyl 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oate

Description	Azido-PEG5-PFP ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.