200417-68-1

200417-68-1 structure

200417-68-1 structure

Name: Thymine-13C
Chemical Name: ThyMine-13C1
CAS Number: 200417-68-1
Molecular Formula: C₅H₆N₂O₂
Molecular Weight: 127.12234
Create Date: 2018-07-02 07:36:45
Modify Date: 2024-02-06 23:17:14
Thymine-13C is the 13C labeled Thymine[1]. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[2].

Name	ThyMine-13C1

Description	Thymine-13C is the 13C labeled Thymine[1]. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[2].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6.

Molecular Formula	C₅H₆N₂O₂
Molecular Weight	127.12234