499212-74-7

499212-74-7 structure

Name: Pritumumab
Chemical Name: Pritumumab
CAS Number: 499212-74-7
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Cancer
Create Date: 2018-11-25 22:54:14
Modify Date: 2024-01-03 16:56:07
Pritumumab is a natural human IgG1kappa mAb originally isolated from a regional draining lymph node of a patient with cervical carcinoma. Pritumumab recognizes vimentin expressing on the cell surface of the malignant tumor. Pritumumab can be used for glioblastoma research[1][2].

Name	Pritumumab

Description	Pritumumab is a natural human IgG1kappa mAb originally isolated from a regional draining lymph node of a patient with cervical carcinoma. Pritumumab recognizes vimentin expressing on the cell surface of the malignant tumor. Pritumumab can be used for glioblastoma research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vivo	Pritumumab 在裸鼠中有效阻止肿瘤生长，但在SCID小鼠中无效[1]。 Pritumumab 只有在完整的细胞介导免疫存在的情况下，才能限制体内异种移植胶质瘤肿瘤的生长[1]。
References	[1]. Santosh Kesari, et al. Pritumumab binding to glioma cells induces ADCC and inhibits tumor growth. ASCO Annual Meeting I. 2017. [2]. Hugwil AV. The meaning of the anti-cancer antibody CLN-IgG (Pritumumab) generated by human × human hybridoma technology against the cyto-skeletal protein, vimentin, in the course of the treatment of malignancy. Med Hypotheses. 2013 Sep;81(3):489-95.

No Any Chemical & Physical Properties