Name | ALPHA-HEMOLYSIN |
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Description | α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K+ and Ca2+ ion transport, leading to necrotic death of target cells[1]. |
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Related Catalog | |
In Vitro | α-Hemolysin (Staphylococcus aureus) 在 THP-1 细胞中可诱导 IL-1β 分泌和 caspase-1 激活,且是通过 NLRP3-炎性体依赖性 caspase-1 的激活诱导 IL-1β 分泌[1]。 α-Hemolysin (Staphylococcus aureus)(1 µg/mL, 4h) 可以诱导 THP 衍生细胞死亡,需要宿主 NLRP3 信号传导,但不依赖于 caspase-1 激活和 IL-1β 分泌[1]。 |
References |
Appearance | lyophilized powder |
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Storage condition | 2-8°C |
Water Solubility | H2O: soluble0.49 - 0.51mg/mL |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319 |
Precautionary Statements | P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
Hazard Codes | Xn |
Risk Phrases | 22-21/22 |
Safety Phrases | 36-36/37 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |