Top Suppliers:I want be here


94716-94-6

94716-94-6 structure
94716-94-6 structure
  • Name: α-Hemolysin (Staphylococcus aureus)
  • Chemical Name: ALPHA-HEMOLYSIN
  • CAS Number: 94716-94-6
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: biological gene Strain and culture
  • Create Date: 2018-12-04 15:04:04
  • Modify Date: 2024-01-08 05:32:26
  • α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K+ and Ca2+ ion transport, leading to necrotic death of target cells[1].

Name ALPHA-HEMOLYSIN
Description α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K+ and Ca2+ ion transport, leading to necrotic death of target cells[1].
Related Catalog
In Vitro α-Hemolysin (Staphylococcus aureus) 在 THP-1 细胞中可诱导 IL-1β 分泌和 caspase-1 激活,且是通过 NLRP3-炎性体依赖性 caspase-1 的激活诱导 IL-1β 分泌[1]。 α-Hemolysin (Staphylococcus aureus)(1 µg/mL, 4h) 可以诱导 THP 衍生细胞死亡,需要宿主 NLRP3 信号传导,但不依赖于 caspase-1 激活和 IL-1β 分泌[1]。
References

[1]. Robin R Craven, et al. Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS One. 2009 Oct 14;4(10):e7446.   

Appearance lyophilized powder
Storage condition 2-8°C
Water Solubility H2O: soluble0.49 - 0.51mg/mL
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases 22-21/22
Safety Phrases 36-36/37
RIDADR NONH for all modes of transport
WGK Germany 3