94716-94-6
94716-94-6 structure
- Name: α-Hemolysin (Staphylococcus aureus)
- Chemical Name: ALPHA-HEMOLYSIN
- CAS Number: 94716-94-6
- Molecular Formula:
- Molecular Weight:
- Catalog: biological gene Strain and culture
- Create Date: 2018-12-04 15:04:04
- Modify Date: 2024-01-08 05:32:26
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α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K+ and Ca2+ ion transport, leading to necrotic death of target cells[1].
| Name | ALPHA-HEMOLYSIN |
|---|
| Description | α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K+ and Ca2+ ion transport, leading to necrotic death of target cells[1]. |
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| Related Catalog | |
| In Vitro | α-Hemolysin (Staphylococcus aureus) 在 THP-1 细胞中可诱导 IL-1β 分泌和 caspase-1 激活，且是通过 NLRP3-炎性体依赖性 caspase-1 的激活诱导 IL-1β 分泌[1]。 α-Hemolysin (Staphylococcus aureus)(1 µg/mL, 4h) 可以诱导 THP 衍生细胞死亡，需要宿主 NLRP3 信号传导，但不依赖于 caspase-1 激活和 IL-1β 分泌[1]。 |
| References |
| Appearance | lyophilized powder |
|---|---|
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble0.49 - 0.51mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn |
| Risk Phrases | 22-21/22 |
| Safety Phrases | 36-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |