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1207727-04-5

1207727-04-5 structure
1207727-04-5 structure
  • Name: broflanilide
  • Chemical Name: broflanilide
  • CAS Number: 1207727-04-5
  • Molecular Formula: C25H14BrF11N2O2
  • Molecular Weight: 663.277
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
  • Create Date: 2018-08-20 22:32:54
  • Modify Date: 2025-08-21 18:07:44
  • Broflanilide is a potential insecticide and metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM.

Name broflanilide
Synonyms 3-[Benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoro-2-propanyl)-6-(trifluoromethyl)phenyl]-2-fluorobenzamide
6′-Bromo-α,α,α,2-tetrafluoro-3-(N-methylbenzamido)-4′-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]benz-o-toluidide
FXFFXFXFFFR CE EXFFF DMVR BF CN1&VR
broflanilide
3-(Benzoylmethylamino)-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide
Benzamide, 3-(benzoylmethylamino)-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluoro-
Description Broflanilide is a potential insecticide and metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM.
Related Catalog
In Vitro Broflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC50s, 0.706, 0.149 μM)[1].
References

[1]. Nakao T, et al. Broflanilide: A meta-diamide insecticide with a novel mode of action. Bioorg Med Chem. 2016 Feb 1;24(3):372-7.

Density 1.6±0.1 g/cm3
Boiling Point 467.9±45.0 °C at 760 mmHg
Molecular Formula C25H14BrF11N2O2
Molecular Weight 663.277
Flash Point 236.8±28.7 °C
Exact Mass 662.006287
LogP 5.30
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.538
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