1228088-30-9

1228088-30-9 structure

Name: Balovaptan
Chemical Name: balovaptan
CAS Number: 1228088-30-9
Molecular Formula: C₂₂H₂₄ClN₅O
Molecular Weight: 409.912
Catalog: Signaling Pathways GPCR/G Protein Vasopressin Receptor
Create Date: 2018-10-07 14:46:22
Modify Date: 2024-01-10 18:39:03
Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

Name	balovaptan
Synonyms	4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-5,6-dihydro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]- RAX5D5AGV6 8-Chloro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine 10298 balovaptan

Description	Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Research Areas >> Neurological Disease
Target	Ki: 1 nM (hV1a), 39 nM (mV1a)[1]
In Vitro	Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for hV1a and mhV1a, and is used for the research of autism. Balovaptan shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1].
References	[1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.