Name | GNE 5729 |
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Synonyms |
MFCD30829916
(1R,2R)-2-(7-Chloro-2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropanecarbonitrile Cyclopropanecarbonitrile, 2-[7-chloro-2-[[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl]-, (1R,2R)- |
Description | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. |
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Related Catalog | |
Target |
EC50: 37 nM (GluN2A), 4.7 μM (GluN2C), 9.5 μM (GluN2D)[1] |
In Vitro | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively[1]. |
References |
Density | 1.7±0.1 g/cm3 |
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Boiling Point | 527.6±60.0 °C at 760 mmHg |
Molecular Formula | C17H10Cl2F3N5O |
Molecular Weight | 428.195 |
Flash Point | 272.9±32.9 °C |
Exact Mass | 427.021454 |
LogP | 2.73 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.702 |