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  • DC Chemicals Limited
  • China
  • Product Name: Gne-5729
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

2026635-66-3

2026635-66-3 structure
2026635-66-3 structure
  • Name: GNE 5729
  • Chemical Name: GNE 5729
  • CAS Number: 2026635-66-3
  • Molecular Formula: C17H10Cl2F3N5O
  • Molecular Weight: 428.195
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
  • Create Date: 2018-08-22 00:50:18
  • Modify Date: 2024-01-12 16:08:43
  • GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.

Name GNE 5729
Synonyms MFCD30829916
(1R,2R)-2-(7-Chloro-2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropanecarbonitrile
Cyclopropanecarbonitrile, 2-[7-chloro-2-[[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl]-, (1R,2R)-
Description GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
Related Catalog
Target

EC50: 37 nM (GluN2A), 4.7 μM (GluN2C), 9.5 μM (GluN2D)[1]

In Vitro GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively[1].
References

[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.

Density 1.7±0.1 g/cm3
Boiling Point 527.6±60.0 °C at 760 mmHg
Molecular Formula C17H10Cl2F3N5O
Molecular Weight 428.195
Flash Point 272.9±32.9 °C
Exact Mass 427.021454
LogP 2.73
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.702