Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FT-1518
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1313026-58-2

1313026-58-2 structure

1313026-58-2 structure

Name: FT-1518
Chemical Name: FT-1518
CAS Number: 1313026-58-2
Molecular Formula: C₂₀H₂₆N₈O
Molecular Weight: 394.47
Catalog: Research Areas Cancer
Create Date: 2018-08-30 04:15:15
Modify Date: 2025-10-23 10:42:24
FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.

Name	FT-1518

Description	FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.
Related Catalog	Research Areas >> Cancer
Target	mTORC1 mTORC2
In Vitro	FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 displays significant growth inhibitory activity against a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. FT-1518 cuases potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)] in cells[1].
In Vivo	FT-1518 exhibits dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts[1].
References	[1]. Alain C. Mita, et al. Abstract 137: FT-1518, a new generation selective and potent mTORC1 and mTORC2 inhibitor: an in vitro and in vivo profile. Cancer Res 2017;77(13 Suppl).

Molecular Formula	C₂₀H₂₆N₈O
Molecular Weight	394.47

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