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  • DC Chemicals Limited
  • China
  • Product Name: GSK963
  • Price: $550.0/100mg $950.0/250mg $1900.0/1g
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao

2049868-46-2

2049868-46-2 structure
2049868-46-2 structure
  • Name: GSK963
  • Chemical Name: 1-​Propanone, 1-​[(5S)​-​4,​5-​dihydro-​5-​phenyl-​1H-​pyrazol-​1-​yl]​-​2,​2-​dimethyl-
  • CAS Number: 2049868-46-2
  • Molecular Formula: C14H18N2O
  • Molecular Weight: 230.31
  • Catalog: Signaling Pathways Apoptosis RIP kinase
  • Create Date: 2018-08-22 17:23:00
  • Modify Date: 2024-01-03 15:32:28
  • GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].

Name 1-​Propanone, 1-​[(5S)​-​4,​5-​dihydro-​5-​phenyl-​1H-​pyrazol-​1-​yl]​-​2,​2-​dimethyl-
Synonyms (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
Description GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].
Related Catalog
Target

IC50: 29 nM (RIP1 in FP binding assay)[1].

References

[1]. Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.

Density 1.06±0.1 g/cm3
Boiling Point 342.8±45.0 °C
Molecular Formula C14H18N2O
Molecular Weight 230.31
Storage condition -20℃