1835705-53-7

1835705-53-7 structure

Name: Boc-C1-PEG2-C4-Cl
Chemical Name: PROTAC Linker 1
CAS Number: 1835705-53-7
Molecular Formula: C₁₄H₂₇ClO₄
Molecular Weight: 294.81
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-09-30 08:53:32
Modify Date: 2025-09-10 16:32:49
PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

Name	PROTAC Linker 1

Description	PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.
Related Catalog	Signaling Pathways >> PROTAC >> PROTAC Linker Research Areas >> Cancer
In Vitro	PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. PROTAC Linker 1 is designated as 6-2-2[1].
References	[1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.