1883650-96-1
1883650-96-1 structure
- Name: CDDO-2P-Im
- Chemical Name: CDDO-3-P-Im
- CAS Number: 1883650-96-1
- Molecular Formula: C39H46N4O3
- Molecular Weight: 618.81
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-12-22 11:14:08
- Modify Date: 2024-01-10 17:14:19
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CDDO-2P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-2P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model[1].
| Name | CDDO-3-P-Im |
|---|---|
| Synonyms | Oleana-1,9(11)-diene-2-carbonitrile,3,12,28-trioxo-28-[4-(2-pyridinyl)-1H-imidazol-1-yl]- |
| Description | CDDO-2P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-2P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model[1]. |
|---|---|
| Related Catalog | |
| In Vitro | CDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM[1]. CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC50 of 5.8 nM[1]. Apoptosis Analysis[1] Cell Line: U937 cells Concentration: 30 nM, 100 nM Incubation Time: 4 days Result: Induced differentiation of U937 cells at 100 nM. |
| In Vivo | CDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies[1]. CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo[1]. CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice[1]. Animal Model: Seven week-old female A/J mice[1] Dosage: 50 mg/kg, 200 mg/kg Administration: Diet; for 16 weeks Result: Decreased the number, the size and the severity of tumors. |
| References |
| Molecular Formula | C39H46N4O3 |
|---|---|
| Molecular Weight | 618.81 |