315698-17-0
315698-17-0 structure
- Name: ML 311
- Chemical Name: ML311
- CAS Number: 315698-17-0
- Molecular Formula: C23H24F3N3O
- Molecular Weight: 415.45
- Catalog: Signaling Pathways Apoptosis Bcl-2 Family
- Create Date: 2019-01-20 08:34:20
- Modify Date: 2024-02-26 13:23:51
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ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
| Name | ML311 |
|---|
| Description | ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction. |
|---|---|
| Related Catalog | |
| Target |
Mcl-1 Bim |
| In Vitro | ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types[1]. |
| References |
| Molecular Formula | C23H24F3N3O |
|---|---|
| Molecular Weight | 415.45 |
| Storage condition | 2-8℃ |