2099142-76-2
2099142-76-2 structure
- Name: BAY-850
- Chemical Name: BAY-850
- CAS Number: 2099142-76-2
- Molecular Formula: C38H44ClN5O3
- Molecular Weight: 654.24
- Catalog: Research Areas Metabolic Disease
- Create Date: 2019-02-10 11:45:54
- Modify Date: 2024-01-03 12:36:59
-
BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.
| Name | BAY-850 |
|---|
| Description | BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM. |
|---|---|
| Related Catalog | |
| Target |
ATAD2[1]. |
| In Vitro | BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD with an IC50 of 166 nM measured in TR-FRET assay. BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157 nM and a KD of 115 nM respectively. The unprecedented isoform selectivity of BAY-850 suggests a different mode of action to those exhibited by canonical BD inhibitors[1]. |
| References |
| Molecular Formula | C38H44ClN5O3 |
|---|---|
| Molecular Weight | 654.24 |