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  • DC Chemicals Limited
  • China
  • Product Name: BAY-850
  • Price: $950.0/100mg $1700.0/250mg $3400.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2099142-76-2

2099142-76-2 structure
2099142-76-2 structure
  • Name: BAY-850
  • Chemical Name: BAY-850
  • CAS Number: 2099142-76-2
  • Molecular Formula: C38H44ClN5O3
  • Molecular Weight: 654.24
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2019-02-10 11:45:54
  • Modify Date: 2024-01-03 12:36:59
  • BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.

Name BAY-850
Description BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.
Related Catalog
Target

ATAD2[1].

In Vitro BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD with an IC50 of 166 nM measured in TR-FRET assay. BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157 nM and a KD of 115 nM respectively. The unprecedented isoform selectivity of BAY-850 suggests a different mode of action to those exhibited by canonical BD inhibitors[1].
References

[1]. Fernández-Montalván AE, et al. Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action. ACS Chem Biol. 2017 Nov 17;12(11):2730-2736.

Molecular Formula C38H44ClN5O3
Molecular Weight 654.24