1884710-81-9
1884710-81-9 structure
- Name: Cbz-B3A
- Chemical Name: Cbz-B3A
- CAS Number: 1884710-81-9
- Molecular Formula: C35H58N6O9
- Molecular Weight: 706.87
- Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
- Create Date: 2019-02-14 09:32:47
- Modify Date: 2024-03-07 10:35:20
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Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).
| Name | Cbz-B3A |
|---|
| Description | Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1). |
|---|---|
| Related Catalog | |
| Target |
mTORC1 signaling[1]. |
| In Vitro | Cbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic. Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins. Cbz-B3A decreases the incorporation of [35S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC50 of ~3 μM. |
| References |
| Molecular Formula | C35H58N6O9 |
|---|---|
| Molecular Weight | 706.87 |
| Hazard Codes | Xi |
|---|