1416581-40-2
1416581-40-2 structure
- Name: MK-8318
- Chemical Name: MK-8318
- CAS Number: 1416581-40-2
- Molecular Formula: C27H26F4N2O5
- Molecular Weight: 534.50
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2019-02-18 18:09:46
- Modify Date: 2024-01-31 18:38:41
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MK-8318 is potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.
| Name | MK-8318 |
|---|
| Description | MK-8318 is potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM. |
|---|---|
| Related Catalog | |
| Target |
CRTH2/DP2 Receptor:5.0 nM (Ki) β-arrestin:3.5 nM (IC50) cAMP:8.0 nM (IC50) CYP3A4:50 μM (IC50) CYP2C9:50 μM (IC50) CYP2D6:50 μM (IC50) |
| In Vitro | MK-8318 also inhibits β-arrestin, cAMP, CYP3A4, CYP2C9, and CYP2D6 with IC50s of 3.5±2.1 nM, 8.0±6.8 nM, 50 µM, 50 µM and 50 µM[1]. |
| In Vivo | In a sheep model, MK-8318 blocks late airway response (LAR) and airway hyperresponsiveness (AHR) after i.v. infusion at 1 mpk. MK-8318 shows 76% LAR efficacy and 114% AHR efficacy[1]. |
| References |
| Molecular Formula | C27H26F4N2O5 |
|---|---|
| Molecular Weight | 534.50 |