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183721-13-3

183721-13-3 structure
183721-13-3 structure
  • Name: MRS1177
  • Chemical Name: MRS1177
  • CAS Number: 183721-13-3
  • Molecular Formula: C20H12ClN5O2
  • Molecular Weight: 389.79
  • Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
  • Create Date: 2019-02-11 23:23:49
  • Modify Date: 2024-01-14 00:28:30
  • MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM.

Name MRS1177
Description MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM.
Related Catalog
Target

Ki: 0.3 nM (hA3AR)[1][2].

In Vitro MRS1177 (compound 2b) is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist[1]. The Ki value of MRS1177 (compound 55) with hA3AR is 0.3 nM[2].
References

[1]. Tafi A, et al. Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97.

[2]. Cheong SL, et al. Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21(10):2898-905.

Molecular Formula C20H12ClN5O2
Molecular Weight 389.79
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