MRS1177

Modify Date: 2025-08-25 19:47:16

MRS1177 Structure
MRS1177 structure
Common Name MRS1177
CAS Number 183721-13-3 Molecular Weight 389.79
Density N/A Boiling Point N/A
Molecular Formula C20H12ClN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MRS1177


MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM.

 Names

Name MRS1177

 MRS1177 Biological Activity

Description MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM.
Related Catalog
Target

Ki: 0.3 nM (hA3AR)[1][2].

In Vitro MRS1177 (compound 2b) is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist[1]. The Ki value of MRS1177 (compound 55) with hA3AR is 0.3 nM[2].
References

[1]. Tafi A, et al. Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97.

[2]. Cheong SL, et al. Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21(10):2898-905.

 Chemical & Physical Properties

Molecular Formula C20H12ClN5O2
Molecular Weight 389.79
InChIKey XIEBLXLGWFCYEP-UHFFFAOYSA-N
SMILES O=C(Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12)c1ccccc1
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