Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nec-4
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1041644-43-2

1041644-43-2 structure

1041644-43-2 structure

Name: Nec-4
Chemical Name: Nec-4
CAS Number: 1041644-43-2
Molecular Formula: C₁₅H₁₃ClFN₃O
Molecular Weight: 305.73
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2019-02-08 13:58:18
Modify Date: 2024-01-14 17:05:10
Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.

Name	Nec-4

Description	Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Others
Target	IC50: 2.6 μM (RIP1)[1].
In Vitro	Nec-4 (compound 9) is a slightly better competitor than 7 with a lower Ki value that is similar to R-3. Nec-4 is again a slightly better competitor than Rac-3 with Ki and IC50 values comparable to 7 (Nec-4: IC50=2.6±0.1 μM, Ki=0.46±0.05 μM; 7: IC50=10.7±1.8 μM, Ki=4.5±0.9 μM). Overall, all three compounds cross-compete with each other but Nec-4 is able to more effectively displace both 20 and 26 in comparison to the parent compounds Rac-3 and 7, respectively. This suggests that Nec-4 binding likely significantly overlaps with both the Nec-1 and the Nec-3 binding sites.
References	[1]. Maki JL, et al. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15;427(2):164-74.

Molecular Formula	C₁₅H₁₃ClFN₃O
Molecular Weight	305.73

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