Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SIRT-IN-1
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1431411-60-7

1431411-60-7 structure

1431411-60-7 structure

Name: SIRT-IN-1
Chemical Name: SIRT-IN-1
CAS Number: 1431411-60-7
Molecular Formula: C₁₉H₂₇N₅O₂S
Molecular Weight: 389.52
Catalog: Research Areas Others
Create Date: 2019-02-10 06:07:06
Modify Date: 2024-01-19 09:42:29
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.

Name	SIRT-IN-1

Description	SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.
Related Catalog	Research Areas >> Others
Target	SIRT1:15 nM (IC50) SIRT2:10 nM (IC50) SIRT3:33 nM (IC50)
In Vitro	SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].
References	[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

Molecular Formula	C₁₉H₂₇N₅O₂S
Molecular Weight	389.52

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