SIRT-IN-1

Modify Date: 2024-01-19 09:42:29

SIRT-IN-1 Structure
SIRT-IN-1 structure
Common Name SIRT-IN-1
CAS Number 1431411-60-7 Molecular Weight 389.52
Density N/A Boiling Point N/A
Molecular Formula C19H27N5O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SIRT-IN-1


SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.

 Names

Name SIRT-IN-1

 SIRT-IN-1 Biological Activity

Description SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.
Related Catalog
Target

SIRT1:15 nM (IC50)

SIRT2:10 nM (IC50)

SIRT3:33 nM (IC50)

In Vitro SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].
References

[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

 Chemical & Physical Properties

Molecular Formula C19H27N5O2S
Molecular Weight 389.52
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