1623194-37-5
1623194-37-5 structure
- Name: GPR40 AgoPAM AP5
- Chemical Name: AP5
- CAS Number: 1623194-37-5
- Molecular Formula: C28H28FNO4
- Molecular Weight: 461.52
- Catalog: Signaling Pathways GPCR/G Protein GPR40
- Create Date: 2019-03-03 22:22:20
- Modify Date: 2024-01-16 16:35:19
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AP5 exhibits potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49±0.28 nM against the GPR40 receptor[1].
| Name | AP5 |
|---|
| Description | AP5 exhibits potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49±0.28 nM against the GPR40 receptor[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 0.49±0.28 nM (GPR40 Receptor)[1] |
| In Vitro | AP5 is a potent and selective GPR40 AgoPAM that demonstrates excellent in vivo efficacy. In the GK rat oral glucose tolerance test (oGTT), oral administration of AP5 1 h before an oral dextrose challenge shows that AP5 significantly reduces blood glucose levels compared to the vehicle. AP5 is determined to be more efficacious in this model, demonstrating maximally efficacious glucose lowering at a plasma concentration of 4.9 μM at 10 mg/kg[1]. |
| References |
| Molecular Formula | C28H28FNO4 |
|---|---|
| Molecular Weight | 461.52 |