1799788-94-5
1799788-94-5 structure
- Name: Trk-IN-4
- Chemical Name: Trk-IN-4
- CAS Number: 1799788-94-5
- Molecular Formula: C24H23F4N5O4
- Molecular Weight: 521.46
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Trk Receptor
- Create Date: 2019-03-03 16:36:04
- Modify Date: 2024-01-12 17:29:35
-
Trk-IN-4 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
| Name | Trk-IN-4 |
|---|
| Description | Trk-IN-4 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. |
|---|---|
| Related Catalog | |
| Target |
TrkA:1.9 nM (IC50, in cell-based assays) TrkB:2.6 nM (IC50, in cell-based assays) TrkC:1.1 nM (IC50, in cell-based assays) |
| In Vitro | Trk-IN-4 (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM)[1]. |
| References |
| Molecular Formula | C24H23F4N5O4 |
|---|---|
| Molecular Weight | 521.46 |
| Hazard Codes | Xi |
|---|