1630808-89-7

1630808-89-7 structure

Name: FT113
Chemical Name: FT113
CAS Number: 1630808-89-7
Molecular Formula: C₂₂H₂₀FN₃O₄
Molecular Weight: 409.41
Catalog: Signaling Pathways Metabolic Enzyme/Protease Fatty Acid Synthase (FAS)
Create Date: 2019-03-31 07:56:34
Modify Date: 2024-01-09 19:39:34
FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer both in vitro and in vivo[1].

Name	FT113

Description	FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer both in vitro and in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)
Target	IC50: 213 nM (FASN), 90 nM (FASN, in BT474 cell)[1]
In Vitro	FT113 shows anti-proliferative activity against PC3 and MV-411 cells with IC50s of 47 and 26 nM, respectively[1].
In Vivo	FT113 (5 mg/kg, p.o.) exhibits potent oral bioavailability of 95% and 84% in mice and rats, respectively[1]. FT113 (5, 25, or 50 mg/kg, p.o., twice daily for 16 days) increases malonyl-CoA concentration in tumors, inhibits tumor growth in a dose-dependent manner in mice[1].
References	[1]. Martin MW, et al. Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Bioorg Med Chem Lett. 2019 Apr 15;29(8):1001-1006.

Molecular Formula	C₂₂H₂₀FN₃O₄
Molecular Weight	409.41