1415637-72-7

1415637-72-7 structure

Name: PF-05085727
Chemical Name: PF-05085727
CAS Number: 1415637-72-7
Molecular Formula: C₂₀H₁₈F₃N₇
Molecular Weight: 413.40
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2019-03-31 08:08:33
Modify Date: 2024-01-05 17:28:00
PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM.

Name	PF-05085727

Description	PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease
Target	PDE2A:2 nM (IC50)
References	[1]. Helal CJ, et al. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J Med Chem. 2017 Jul 13;60(13):5673-5698.