2031177-48-5

2031177-48-5 structure

Name: ZM223
Chemical Name: ZM223
CAS Number: 2031177-48-5
Molecular Formula: C₂₃H₁₇F₃N₄O₂S₂
Molecular Weight: 502.53
Catalog: Signaling Pathways Metabolic Enzyme/Protease NEDD8-activating Enzyme
Create Date: 2019-03-30 17:45:34
Modify Date: 2025-08-25 10:36:27
ZM223 is a novel non-sulfamide NEDD8 activating enzyme inhibitor that inhibits HCT116 colon cancer cells with an IC50 value of 100 nM.

Name	ZM223

Description	ZM223 is a novel non-sulfamide NEDD8 activating enzyme inhibitor that inhibits HCT116 colon cancer cells with an IC50 value of 100 nM.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> NEDD8-activating Enzyme
Target	IC50: 100 nM (HCT116), 122 nM (U-2OS)[1]
In Vitro	ZM223 exhibits excellent antitumor activities against both HCT116 and U-2OS cells (IC50=100, 122 nM)[1]. Western Blot Analysis[1] Cell Line: HCT-116 cells Concentration: 0.1, 1 μM Incubation Time: 4 hours Result: ZM223 inhibited NEDD8 protein and subsequently elevated UBC12 level[1].
References	[1]. Ma H, et al. Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. Eur J Med Chem. 2017 Jun 16;133:174-183.