DC Chemicals Limited
China
Product Name: 7-BIA
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1313403-49-4

1313403-49-4 structure

1313403-49-4 structure

Name: 7-BIA
Chemical Name: 7-BIA
CAS Number: 1313403-49-4
Molecular Formula: C₁₅H₁₈O₆
Molecular Weight: 294.30
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2019-06-01 16:20:02
Modify Date: 2024-01-10 13:25:05
7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1].

Name	7-BIA

Description	7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Neurological Disease
Target	IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS)[1]
In Vitro	7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of ~1–3 μM and 40 μM, respectively[1].
In Vivo	7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1]. Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions)[1] Dosage: 10 mg/kg, 20 mg/kg Administration: Given i.p.; only once Result: Reduced cocaine self-administration in highly experienced WT mice.
References	[1]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosinephosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11597-11602.

Molecular Formula	C₁₅H₁₈O₆
Molecular Weight	294.30