1638526-94-9
1638526-94-9 structure
- Name: Bax activator compound 106
- Chemical Name: Bax activator-1
- CAS Number: 1638526-94-9
- Molecular Formula: C29H36N4O3
- Molecular Weight: 488.62
- Catalog: Signaling Pathways Apoptosis Bcl-2 Family
- Create Date: 2019-06-02 13:53:33
- Modify Date: 2024-01-11 18:56:38
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Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1].
| Name | Bax activator-1 |
|---|
| Description | Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1]. |
|---|---|
| Related Catalog | |
| Target |
Bax |
| In Vitro | Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion[1]. Apoptosis Analysis[1] Cell Line: Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells Concentration: 20 μM, 40 μM , 60 μM , 80 μM Incubation Time: 48 hours Result: Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion. |
| In Vivo | Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice[1]. Animal Model: Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)[1] Dosage: 40 mg/kg Administration: Given i.p., each day for 13 days Result: Exhibited anti-tumor activity as a single-agent. |
| References |
| Molecular Formula | C29H36N4O3 |
|---|---|
| Molecular Weight | 488.62 |