1227948-02-8

1227948-02-8 structure

Name: BI-4464
Chemical Name: BI-4464
CAS Number: 1227948-02-8
Molecular Formula: C₂₈H₂₈F₃N₅O₄
Molecular Weight: 555.55
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FAK
Create Date: 2019-06-01 19:24:46
Modify Date: 2026-07-05 21:02:53
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].

Name	BI-4464
Synonyms	BI-4464 (BI4464 BI 4464) 3-Methoxy-N-(1-methylpiperidin-4-yl)-4-((4-((3-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide Benzamide, 4-[[4-[(2,3-dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl) Tget Protein-binding Moiety,Inhibitor,BI 4464,Focal adhesion kinase,BI-4464,BI4464,inhibit,PTK2 protein tyrosine kinase 2,Ligands for Tget Protein for PROTAC,PTK2,FAK

Description	BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK
Target	IC50: 17 nM (PTK2/FAK)[1].
References	[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.