1628574-81-1

1628574-81-1 structure

Name: c-Fms-IN-6
Chemical Name: c-Fms-IN-6
CAS Number: 1628574-81-1
Molecular Formula: C₂₂H₂₅N₇O₂
Molecular Weight: 419.48
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
Create Date: 2019-06-02 11:16:56
Modify Date: 2025-09-18 17:06:39
c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC50 of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50, > 1 μM). Used in the research of autoimmune diseases[1].

Name	c-Fms-IN-6

Description	c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC50 of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50, > 1 μM). Used in the research of autoimmune diseases[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms
Target	IC50: ≤10 nM (c-FMS)[1]
In Vitro	c-Fms-IN-6 (Example 38) shows inhibitory activity against M-NFS-60 cell proliferation, with an IC50 in the range of 0.01 μM to 0.1 μM[1].
References	[1]. Gary E. L. BRANDT, et al. 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities. WO2014145023A1.

Molecular Formula	C₂₂H₂₅N₇O₂
Molecular Weight	419.48