2234281-75-3
2234281-75-3 structure
- Name: JI051
- Chemical Name: JI051
- CAS Number: 2234281-75-3
- Molecular Formula: C22H24N2O3
- Molecular Weight: 364.44
- Catalog: Signaling Pathways Stem Cell/Wnt Notch
- Create Date: 2019-06-02 11:21:56
- Modify Date: 2024-04-03 03:58:13
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JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].
| Name | JI051 |
|---|
| Description | JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1]. |
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| Related Catalog | |
| In Vitro | JI051 causes G2/M cell-cycle arrest[1]. JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1]. Cell Proliferation Assay[1] Cell Line: HEK293 cells Concentration: 0.1-10 µM Incubation Time: 24 hours Result: Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations. |
| References |
| Molecular Formula | C22H24N2O3 |
|---|---|
| Molecular Weight | 364.44 |
| Storage condition | 2-8℃ |