1542213-00-2

1542213-00-2 structure

Name: NCT-502
Chemical Name: NCT-502
CAS Number: 1542213-00-2
Molecular Formula: C₁₈H₂₀F₃N₅S
Molecular Weight: 395.45
Catalog: Research Areas Cancer
Create Date: 2019-06-05 20:58:34
Modify Date: 2024-07-19 10:05:22
NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1].

Name	NCT-502

Description	NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 3.7 μM (PHGDH)[1]
In Vitro	NCT-502 is cytotoxic to MDA-MB-468, with an EC50 of 15.2 µM[1].
References	[1]. Rohde JM, et al. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorg Med Chem. 2018 May 1;26(8):1727-1739.