2222344-98-9
2222344-98-9 structure
- Name: ORIC-101
- Chemical Name: ORIC-101
- CAS Number: 2222344-98-9
- Molecular Formula: C34H47NO2
- Molecular Weight: 501.74
- Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
- Create Date: 2019-06-01 22:55:56
- Modify Date: 2024-01-05 15:32:16
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ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity.
| Name | ORIC-101 |
|---|
| Description | ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity. |
|---|---|
| Related Catalog | |
| Target |
EC50: 5.6 nM (Glucocorticoid receptor)[1] |
| In Vitro | ORIC-101 shows markedly reduced androgen receptor agonism (EC50, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC50, >10 μM)[1]. ORIC-101 (1-1000 nM) dose-dependently reduces the expression of n GR-mediated target gene (FKBP5 and GILZ), with IC50s of 17.2 and 21.2 nM, respectively[1]. |
| In Vivo | ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice[1]. Animal Model: OVCAR5 xenograft tumor in cortisol-treated mice[1] Dosage: 75 mg/kg with 100 mg/kg gemcitabine and 60 mg/kg carboplatin Administration: P.O. twice a day for 16-22 days Result: Significantly reduced tumor volume in combination with chemotherapeutic agents. |
| References |
| Molecular Formula | C34H47NO2 |
|---|---|
| Molecular Weight | 501.74 |