Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PDE9-IN-1
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Purity: 99.0%
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2305087-92-5

2305087-92-5 structure

2305087-92-5 structure

Name: PDE9-IN-1
Chemical Name: PDE9-IN-1
CAS Number: 2305087-92-5
Molecular Formula: C₁₇H₂₃FN₆O₂
Molecular Weight: 362.40
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2019-06-01 16:59:40
Modify Date: 2025-08-20 12:21:48
PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC50 of 8.7 nM[1].

Name	PDE9-IN-1

Description	PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC50 of 8.7 nM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease
Target	PDE9A:8.7 nM (IC50)
In Vitro	PDE9-IN-1 is excellent selectivity across PDE families[1].
In Vivo	PDE9-IN-1 (2.5 and 5.0 mg/kg; Oral administration; daily for 21 days) effectively recovers learning and memory function[1]. Animal Model: Unilateral common carotid artery occlusion (UCCAO) mouse model[1] Dosage: 2.5 and 5.0 mg/kg Administration: Oral administration; daily for 21 days Result: Significantly reduced the day 6 escape latency time and increased the frequency of platform area crossings, and recovered learning and memory function. High dose group possibly improved the escape latency time of mice.
References	[1]. Wu Y, et al. Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. J Med Chem. 2019 Apr 25;62(8):4218-4224.

Molecular Formula	C₁₇H₂₃FN₆O₂
Molecular Weight	362.40

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