1862237-99-7

1862237-99-7 structure

Name: SirReal1-O-propargyl
Chemical Name: PROTAC Sirt2-binding moiety 1
CAS Number: 1862237-99-7
Molecular Formula: C₂₁H₂₀N₄O₂S₂
Molecular Weight: 424.54
Catalog: Research Areas Others
Create Date: 2019-06-02 13:01:56
Modify Date: 2025-09-09 15:10:33
PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1].

Name	PROTAC Sirt2-binding moiety 1

Description	PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1].
Related Catalog	Research Areas >> Others
Target	IC50: 2.4 μM (Sirt2)[1].
References	[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.