SirReal1-O-propargyl

Modify Date: 2024-01-20 13:10:27

SirReal1-O-propargyl Structure
SirReal1-O-propargyl structure
Common Name SirReal1-O-propargyl
CAS Number 1862237-99-7 Molecular Weight 424.54
Density N/A Boiling Point N/A
Molecular Formula C21H20N4O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SirReal1-O-propargyl


PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1].

 Names

Name PROTAC Sirt2-binding moiety 1

 SirReal1-O-propargyl Biological Activity

Description PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1].
Related Catalog
Target

IC50: 2.4 μM (Sirt2)[1].

References

[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

 Chemical & Physical Properties

Molecular Formula C21H20N4O2S2
Molecular Weight 424.54
Storage condition 2-8℃