2222755-14-6

2222755-14-6 structure

Name: LOXO-292
Chemical Name: RET-IN-1
CAS Number: 2222755-14-6
Molecular Formula: C₂₉H₃₁N₉O₃
Molecular Weight: 553.61
Catalog: Research Areas Cancer
Create Date: 2019-06-01 16:15:46
Modify Date: 2024-01-05 14:05:07
RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].

Name	RET-IN-1
Synonyms	LOXO-292

Description	RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 1 nM (RETWT), 7 nM (RETV804M), 101 nM (RETG810R)
References	[1]. Steven W A, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.